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Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways

Artikel i vetenskaplig tidskrift
Författare Niek Welkenhuysen
Barbara Schnitzer
Linnea Österberg
Marija Cvijovic
Publicerad i Frontiers in Physiology
Volym 9
ISSN 1664-042X
Publiceringsår 2019
Publicerad vid Institutionen för matematiska vetenskaper
Språk en
Länkar dx.doi.org/10.3389/fphys.2018.01964
Ämnesord nutrient signaling, cAMP-PKA pathway, Snf1 pathway, Snf3/Rgt2 pathway, logic modeling, Boolean, protein-kinase-a, nitrogen catabolite repression, yeast yak1 kinase, saccharomyces-cerevisiae, dependent transcription, regulatory, mechanisms, nuclear-localization, glucose regulation, adenylate-cyclase, snf1 kinase
Ämneskategorier Bioinformatik och systembiologi

Sammanfattning

Systems biology approaches provide means to study the interplay between biological processes leading to the mechanistic understanding of the properties of complex biological systems. Here, we developed a vector format rule-based Boolean logic model of the yeast S. cerevisiae cAMP-PKA, Snf1, and the Snf3-Rgt2 pathway to better understand the role of crosstalk on network robustness and function. We identified that phosphatases are the common unknown components of the network and that crosstalk from the cAMP-PKA pathway to other pathways plays a critical role in nutrient sensing events. The model was simulated with known crosstalk combinations and subsequent analysis led to the identification of characteristics and impact of pathway interconnections. Our results revealed that the interconnections between the Snf1 and Snf3-Rgt2 pathway led to increased robustness in these signaling pathways. Overall, our approach contributes to the understanding of the function and importance of crosstalk in nutrient signaling.

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