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Evidence of increased fecal granins in children with irritable bowel syndrome and correlates with symptoms

Artikel i vetenskaplig tidskrift
Författare R. J. Shulman
Lena Öhman
M. Stridsberg
K. Cain
Magnus Simrén
M. Heitkemper
Publicerad i Neurogastroenterology and Motility
Volym 31
Nummer/häfte 1
ISSN 1350-1925
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Språk en
Länkar dx.doi.org/10.1111/nmo.13486
Ämnesord children, chromogranin, irritable bowel syndrome, pediatric, secretogranin, functional gastrointestinal disorders, recurrent abdominal-pain, serum, chromogranin-a, stool form scale, immune activation, intestinal, microbiota, secretogranin-ii, acetic-acid, childhood, calprotectin, Gastroenterology & Hepatology, Neurosciences & Neurology, ridsberg m, 1995, journal of endocrinology, v144, p49
Ämneskategorier Gastroenterologi

Sammanfattning

Background Granins have been implicated in the pathophysiology of irritable bowel syndrome (IBS) in adults. We sought to determine whether fecal granins are altered in children with IBS and associated with symptoms. Methods Children (7-12 years of age) with IBS and healthy controls (HC) kept daily pain and stool diaries for 2 weeks. Stool samples were analyzed for chromogranins A and B (CgA, CgB) and secretogranins II and III (SgII, SgIII). Children also completed psychological measures to assess anxiety, depression, somatization, and internalizing symptoms. Key Results Fecal CgB and SgIII concentrations were higher in all the boys (IBS plus HC, n = 48) than in all the girls (IBS plus HC, n = 75) (P = 0.02 and P = 0.046, respectively). CgA and SgIII were greater in children with IBS (n = 52) vs HC (n = 69) (P = 0.01, P = 0.017, respectively). CgB and SgII did not differ between groups. In children with IBS, the number of pain episodes per week and mean daily pain rating correlated positively with all four granins. The number of stools per day correlated positively with CgB and SgII, and the percent of diarrheal stools (6 or 7 on the Bristol Scale) correlated inversely with all four granins in boys but not in girls. Fecal granins did not correlate with psychological measures. Conclusions and Inferences As measured by fecal granins, there is evidence of neuroimmune activation in children with IBS. Granins are related to abdominal pain symptoms, stooling frequency, and stool form in children with IBS. Sex influences the fecal concentration of CgB and SgIII.

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