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The recency ratio is related to CSF amyloid beta 1-42 levels in MCI-AD.

Artikel i vetenskaplig tidskrift
Författare Davide Bruno
Carey E Gleason
Rebecca L Koscik
Nunzio Pomara
Henrik Zetterberg
Kaj Blennow
Sterling C Johnson
Publicerad i International journal of geriatric psychiatry
Volym 34
Nummer/häfte 3
Sidor 415-419
ISSN 1099-1166
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 415-419
Språk en
Länkar dx.doi.org/10.1002/gps.5029
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Neurokemi

Sammanfattning

As anti-amyloid therapeutic interventions shift from enrolling patients with Alzheimer's disease (AD) dementia to individuals with pre-clinical disease, the need for sensitive measures that allow for non-invasive, fast, disseminable, and cost-effective identification of preclinical status increases in importance. The recency ratio (Rr) is a memory measure that relies on analysis of serial position performance, which has been found to predict cognitive decline and conversion to early mild cognitive impairment (MCI). The aim of this study was to test Rr's sensitivity to cerebrospinal fluid (CSF) levels of the core AD biomarkers in individuals with MCI-AD and controls.Baseline data from 126 (110 controls and 16 MCI-AD) participants from the Wisconsin Alzheimer's Disease Research Center were analysed. Partial correlations adjusting for demographics were carried out between CSF measure of amyloid beta (Aβ40, Aβ42, and the 40/42 ratio) and tau (total and phosphorylated), and memory measures (Rr, delayed recall, and total recall) derived from the Rey's Auditory Verbal Learning Test.Results indicated that Rr was the most sensitive memory score to Aβ42 levels in MCI-AD, while no memory score correlated significantly with any biomarker in controls.This study shows that Rr is a sensitive cognitive index of underlying amyloid β pathology in MCI-AD.

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