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Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts

Artikel i vetenskaplig tidskrift
Författare R. Huhtaniemi
R. Oksala
M. Knuuttila
A. Mehmood
E. Aho
T. D. Laajala
D. Nicorici
T. Aittokallio
A. Laiho
L. Elo
Claes Ohlsson
P. Kallio
S. Mäkelä
M. V. J. Mustonen
P. Sipilä
Matti Poutanen
Publicerad i American Journal of Pathology
Volym 188
Nummer/häfte 12
Sidor 2890-2901
ISSN 0002-9440
Publiceringsår 2018
Publicerad vid Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 2890-2901
Språk en
Länkar dx.doi.org/10.1016/j.ajpath.2018.07...
Ämneskategorier Patologi

Sammanfattning

The role of adrenal androgens as drivers for castration-resistant prostate cancer (CRPC) growth in humans is generally accepted; however, the value of preclinical mouse models of CRPC is debatable, because mouse adrenals do not produce steroids activating the androgen receptor. In this study, we confirmed the expression of enzymes essential for de novo synthesis of androgens in mouse adrenals, with high intratissue concentration of progesterone (P4) and moderate levels of androgens, such as androstenedione, testosterone, and dihydrotestosterone, in the adrenal glands of both intact and orchectomized (ORX) mice. ORX alone had no effect on serum P4 concentration, whereas orchectomized and adrenalectomized (ORX + ADX) resulted in a significant decrease in serum P4 and in a further reduction in the low levels of serum androgens (androstenedione, testosterone, and dihydrotestosterone), measured by mass spectrometry. In line with this, the serum prostate-specific antigen and growth of VCaP xenografts in mice after ORX + ADX were markedly reduced compared with ORX alone, and the growth difference was not abolished by a glucocorticoid treatment. Moreover, ORX + ADX altered the androgen-dependent gene expression in the tumors, similar to that recently shown for the enzalutamide treatment. These data indicate that in contrast to the current view, and similar to humans, mouse adrenals synthesize significant amounts of steroids that contribute to the androgen receptor–dependent growth of CRPC. © 2018 American Society for Investigative Pathology

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