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The relationship between affective symptoms and hypertension-role of the labelling effect: the 1946 British birth cohort.

Artikel i vetenskaplig tidskrift
Författare Valérie Tikhonoff
Rebecca Hardy
John Deanfield
Peter Friberg
Graciela Muniz
Diana Kuh
Carmine M Pariante
Matthew Hotopf
Marcus Richards
Publicerad i Open heart
Volym 3
Nummer/häfte 1
Sidor e000341
ISSN 2053-3624
Publiceringsår 2016
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor e000341
Språk en
Länkar dx.doi.org/10.1136/openhrt-2015-000...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Kardiologi

Sammanfattning

To investigate the association between repeated measures of affective symptoms collected over 2 decades and hypertension (clinically ascertained or self-report); to test whether, among people with hypertension, affective symptoms are associated with awareness of hypertension, and to evaluate the longitudinal effects of the label of hypertension on affective symptoms.Multivariable logistic regression, accounting for confounders and mediators, were used to test the aforementioned associations in 1683 participants from a national British cohort.Weak evidence of a cumulative impact of affective symptoms across adulthood on self-reported hypertension at age 60-64 years was observed (OR 1.40 (95% CI 1.10 to 1.78) and 1.19 (0.79 to 1.80) for symptoms at 1-2 time points and at 3-4 time points vs no symptoms, respectively). Study members with affective symptoms in recent times were more likely to have self-reported hypertension at age 60-64 years than those without symptoms (OR 1.47 (1.10 to 1.96)). Similar results were observed for awareness of hypertension (OR 2.00 (1.30 to 3.06)). Conversely, no associations were found with clinically ascertained hypertension. The act of labelling someone as hypertensive at age 53 years was associated with affective symptoms at age 60-64 years, independently of antihypertensive treatment and affective symptoms at the time of the diagnosis (OR 2.40 (1.32 to 4.36)).Our findings suggest that elevated risk of hypertension in participants with affective symptoms might be explained by awareness of hypertension and by exposure to medical attention, though not by a direct effect of affective symptoms on blood pressure. Conversely, long-term psychological consequences of the label of hypertension are observed.

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