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A three-generation study on the association of tobacco smoking with asthma

Artikel i vetenskaplig tidskrift
Författare S. Accordini
L. Calciano
A. Johannessen
L. Portas
B. Benediktsdottir
R. J. Bertelsen
L. Braback
A. E. Carsin
S. C. Dharmage
J. Dratva
B. Forsberg
F. G. Real
J. Heinrich
J. W. Holloway
Mathias Holm
C. Janson
R. Jogi
B. Leynaert
A. Malinovschi
A. Marcon
J. M. Rovira
C. Raherison
J. Sanchez-Ramos
V. Schlunssen
R. Bono
A. G. Corsico
P. Demoly
S. Arenas
D. Nowak
I. Pin
J. Weyler
D. Jarvis
C. Svanes
Publicerad i International Journal of Epidemiology
Volym 47
Nummer/häfte 4
Sidor 1106-1117
ISSN 0300-5771
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Sidor 1106-1117
Språk en
Länkar dx.doi.org/10.1093/ije/dyy031
Ämnesord Asthma, mothers' smoking during pregnancy, grandmothers' smoking during pregnancy, fathers', respiratory-health-survey, maternal nicotine exposure, obstructive, lung-disease, childhood asthma, transgenerational responses, follow-up, pregnancy, cohort, inheritance, expression
Ämneskategorier Miljömedicin

Sammanfattning

Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged <= 51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.

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