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Contact allergy to oxidized geraniol among Swedish dermatitis patients-A multicentre study by the Swedish Contact Dermatitis Research Group

Artikel i vetenskaplig tidskrift
Författare Lina Hagvall
M. Bruze
M. Engfeldt
M. Isaksson
M. Lindberg
K. Ryberg
B. Stenberg
C. Svedman
A. T. Karlberg
Johanna Bråred Christensson
Publicerad i Contact Dermatitis
Volym 79
Nummer/häfte 4
Sidor 232-238
ISSN 0105-1873
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi
Institutionen för kemi och molekylärbiologi
Sidor 232-238
Språk en
Länkar dx.doi.org/10.1111/cod.13047
Ämnesord allergic contact dermatitis, autoxidation, fragrance contact allergy, fragrance mix I, geraniol, patch, patch test reactions, lavender oil, air exposure, skin sensitization, oxidation-products, linalyl acetate, fragrances, limonene, hydroperoxides, quantification, Allergy, Dermatology
Ämneskategorier Dermatologi och venereologi, Lungmedicin och allergi

Sammanfattning

Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet. Results: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet. Conclusions: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.

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