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Membrane Deformation Induces Clustering of Norovirus Bound to Glycosphingolipids in a Supported Cell-Membrane Mimic

Artikel i vetenskaplig tidskrift
Författare N. Parveen
Inga Rimkute
S. Block
Gustaf E Rydell
D. Midtvedt
Göran Larson
V. P. Hytönen
V. P. Zhdanov
A. Lundgren
F. Höök
Publicerad i Journal of Physical Chemistry Letters
Volym 9
Nummer/häfte 9
Sidor 2278-2284
ISSN 1948-7185
Publiceringsår 2018
Publicerad vid Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Sidor 2278-2284
Språk en
Länkar dx.doi.org/10.1021/acs.jpclett.8b00...
Ämnesord Cell membranes, Cytology, Deformation, Fluorescence microscopy, Gold nanoparticles, Lipid bilayers, Refractive index, Viruses, Affinity receptors, Cellular membranes, Functionalized gold nanoparticles, Glycosphingolipids, Nano-carriers, Norovirus, Quartz crystal microbalance with dissipation monitoring, Total internal reflection fluorescence microscopy, Drug delivery
Ämneskategorier Farmakologi och toxikologi, Fysikalisk kemi

Sammanfattning

Quartz crystal microbalance with dissipation monitoring and total internal reflection fluorescence microscopy have been used to investigate binding of norovirus-like particles (noroVLPs) to a supported (phospho)lipid bilayer (SLB) containing a few percent of H or B type 1 glycosphingolipid (GSL) receptors. Although neither of these GSLs spontaneously form domains, noroVLPs were observed to form micron-sized clusters containing typically up to about 30 VLP copies, especially for B type 1, which is a higher-affinity receptor. This novel finding is explained by proposing a model implying that VLP-induced membrane deformation promotes VLP clustering, a hypothesis that was further supported by observing that functionalized gold nanoparticles were able to locally induce SLB deformation. Because similar effects are likely possible also at cellular membranes, our findings are interesting beyond a pure biophysicochemical perspective as they shed new light on what may happen during receptor-mediated uptake of viruses as well as nanocarriers in drug delivery. © Copyright 2018 American Chemical Society.

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