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Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives

Forskningsöversiktsartikel
Författare R. N. Groen
N. C. de Clercq
Max Nieuwdorp
H. J. R. Hoenders
A. K. Groen
Publicerad i Critical Reviews in Clinical Laboratory Sciences
Volym 55
Nummer/häfte 4
Sidor 283-293
ISSN 1040-8363
Publiceringsår 2018
Publicerad vid Wallenberglaboratoriet
Sidor 283-293
Språk en
Länkar dx.doi.org/10.1080/10408363.2018.14...
Ämnesord Gut-brain axis, bile acid, psychiatry, metabolic syndrome, fecal transplantation, germ free, major depressive disorder, autistic spectrum disorders, irritable-bowel-syndrome, time-series analysis, chain fatty-acids, intestinal microbiota, insulin sensitivity, fecal microbiota, tryptophan-metabolism, network perspective, Medical Laboratory Technology, ates of america, v108, p3047, ates of america, v106, p3698
Ämneskategorier Medicinsk laboratorievetenskap

Sammanfattning

Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.

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