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Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients

Artikel i vetenskaplig tidskrift
Författare Jonathan Aldridge
Jayesh M. Pandya
Linda Meurs
Kerstin Andersson
Inger Nordström
Elke Theander
Anna-Carin Lundell
Anna Rudin
Publicerad i Arthritis Research & Therapy
Volym 20
Nummer/häfte 1
ISSN 1478-6354
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Språk en
Länkar dx.doi.org/10.1186/s13075-018-1648-...
Ämnesord T cells, Rheumatoid arthritis, Disease activity, Sex, human autoimmune arthritis, th1 cells, north-america, frequency, helper, susceptibility, remission, profile, ptpn22, cohort, Rheumatology, evoo mll, 1995, arthritis and rheumatism, v38, p44
Ämneskategorier Reumatologi och inflammation

Sammanfattning

Background: It is not known if sex-based disparities in immunological factors contribute to the disease process in rheumatoid arthritis (RA). Hence, we examined whether circulating T cell subset proportions and their association with disease activity differed in male and female patients with untreated early rheumatoid arthritis (ueRA). Methods: Proportions of T cell subsets were analyzed in peripheral blood from 72 ueRA DMARD-and corticosteroid-naive patients (50 females and 22 males) and in 31 healthy age-and sex-matched controls. Broad analysis of helper and regulatory CD4(+) T cell subsets was done using flow cytometry. Disease activity in patients was assessed using DAS28, CDAI, swollen joint counts, tender joint counts, CRP, and ESR. Results: Multivariate factor analyses showed that male and female ueRA patients display distinct profiles of association between disease activity and circulating T cell subset proportions. In male, but not female, ueRA patients Th2 cells showed a positive association with disease activity and correlated significantly with DAS28-ESR, CDAI, and swollen and tender joint counts. Likewise, proportions of non-regulatory CTLA-4(+) T cells associated positively with disease activity in male patients only, and correlated with DAS28-ESR. In contrast, there was a negative relation between Th1Th17 subset proportions and disease activity in males only. The proportions of Th17 cells correlated positively with DAS28-ESR in males only, while proportions of Th1 cells showed no relation to disease activity in either sex. There were no significant differences in proportions of T cell subsets between the sexes in patients with ueRA. Conclusions: Our findings show sex-based differences in the association between T cell subsets and disease activity in ueRA patients, and that Th2 helper T cells may have a role in regulating disease activity in male patients.

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