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Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Artikel i vetenskaplig tidskrift
Författare Michael L Alosco
Yorghos Tripodis
Nathan G Fritts
Amanda Heslegrave
Christine M Baugh
Shannon Conneely
Megan Mariani
Brett M Martin
Samuel Frank
Jesse Mez
Thor D Stein
Robert C Cantu
Ann C McKee
Leslie M Shaw
John Q Trojanowski
Kaj Blennow
Henrik Zetterberg
Robert A Stern
Publicerad i Alzheimer's & dementia : the journal of the Alzheimer's Association
Volym 14
Nummer/häfte 9
Sidor 1159-1170
ISSN 1552-5279
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 1159-1170
Språk en
Länkar dx.doi.org/10.1016/j.jalz.2018.05.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Neurokemi

Sammanfattning

Cerebrospinal fluid (CSF) protein analysis may facilitate detection and elucidate mechanisms of neurological consequences from repetitive head impacts (RHI), such as chronic traumatic encephalopathy. We examined CSF concentrations of total tau (t-tau), phosphorylated tau, and amyloid β1-42 and their association with RHI in former National Football League (NFL) players. The role of microglial activation (using sTREM2) was examined as a pathogenic mechanism of chronic traumatic encephalopathy.Sixty-eight former NFL players and 21 controls underwent lumbar puncture to quantify t-tau, p-tau181, amyloid β1-42, and sTREM2 in the CSF using immunoassays. The cumulative head impact index estimated RHI.No between-group differences for CSF analytes emerged. In the former NFL players, the cumulative head impact index predicted higher t-tau concentrations (P = .041), and higher sTREM2 levels were associated with higher t-tau concentrations (P = .009).In this sample of former NFL players, greater RHI and increased microglial activation were associated with higher CSF t-tau concentrations.

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