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Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study

Artikel i vetenskaplig tidskrift
Författare I. N. Kuiper
C. Svanes
B. Benediktsdottir
R. J. Bertelsen
L. Braback
S. C. Dharmage
Mathias Holm
C. Janson
R. Jogi
A. Malinovschi
M. Matheson
J. M. Moratalla
F. G. Real
J. L. Sanchez-Ramos
V. Schlunssen
S. Timm
A. Johannessen
Publicerad i Bmc Pulmonary Medicine
Volym 18
Nummer/häfte 122
ISSN 1471-2466
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin
Språk en
Länkar dx.doi.org/10.1186/s12890-018-0687-...
Ämnesord Agreement, Validation, Asthma, Questionnaire, Self-report, Transgenerational, grandmaternal smoking patterns, isaac written questionnaire, childhood, asthma, school-children, validation, allergy, risk, predictors, diagnosis, cohort, Respiratory System
Ämneskategorier Lungmedicin och allergi

Sammanfattning

Background: Self-report questionnaires are commonly used in epidemiology, but may be susceptible to misclassification, especially if answers are given on behalf of others, e.g. children or parents. The aim was to determine agreement and analyse predictors of disagreement in parents' reports of offspring asthma, and in offspring reports of parents' asthma. Methods: In the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study, 6752 offspring (age range 18-51 years) and their parents (age range 39-66 years) reported their own and each other's asthma status. Agreement between asthma reports from offspring and parents was determined by calculating sensitivity, specificity, positive and negative predictive value and Cohen's kappa. The participants' own answers regarding themselves were defined as the gold standard. To investigate predictors for disagreement logistic regression analyses were performed to obtain odds ratios (OR) with 95% confidence intervals (CI) for sex, smoking status, education, comorbidity and severity of asthma. Results: Agreement was good for parental report of offspring early onset asthma (< 10 years, Cohen's kappa 0.72) and moderate for offspring later onset asthma (Cohen's kappa 0.46). Specificity was 0.99 for both, and sensitivity was 0.68 and 0.36, respectively. For offspring report of maternal and paternal asthma the agreement was good (Cohen's kappa 0.69 and 0.68), specificity was 0.96 and 0.97, and sensitivity was 0.72 and 0.68, respectively. The positive predictive value (PPV) was lowest for offspring report of maternal asthma (0.75), and highest for parents' report of early onset asthma in the offspring (0.83). The negative predictive value (NPV) was high for all four groups (0.94-0.97). In multivariate analyses current smokers (OR = 1.46 [95% CI 1.05, 2.02]) and fathers (OR = 1.31 [95% CI 1. 08, 1.59]) were more likely to report offspring asthma incorrectly. Offspring wheeze was associated with reporting parental asthma incorrectly (OR = 1.60 [95% CI 1.21, 2.11]), both under- and over reporting. Conclusions: Asthma reports across generations show moderate to good agreement, making information from other generations a useful tool in the absence of direct reports.

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