Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Strenuous physical exerci… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Strenuous physical exercise adversely affects monocyte chemotaxis

Artikel i vetenskaplig tidskrift
Författare F. S. Czepluch
R. Barres
Kenneth Caidahl
S. Olieslagers
A. Krook
A. Rickenlund
J. R. Zierath
J. Waltenberger
Publicerad i Thrombosis and Haemostasis
Volym 105
Nummer/häfte 1
Sidor 122-30
ISSN 0340-6245
Publiceringsår 2011
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 122-30
Språk en
Länkar https://doi.org/10.1160/TH10-06-036...
Ämnesord Adaptation, Physiological/physiology, Body Mass Index, Chemokine CCL2/blood, *Chemotaxis, Leukocyte, *Exercise, Humans, Lipids/blood, Monocytes/*physiology, Nitric Oxide/blood, Observation, Respiratory Function Tests, Transforming Growth Factor beta1/blood, Vascular Endothelial Growth Factor A/blood
Ämneskategorier Klinisk fysiologi

Sammanfattning

Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-beta1 (TGF-beta1) was completely inhibited immediately after training (p<0.01), and remained so after four weeks recovery. Likewise, monocyte chemoattractant protein-1 (MCP-1)-induced migration declined after training (p<0.01) and improved only partially during the recovery period. MCP-1 serum levels were significantly reduced after four weeks recovery compared to baseline (p<0.01). Total blood antioxidant capacity was enhanced at this time point (p<0.01). Monocyte chemokinesis, TGF-beta1 and nitric oxide serum levels remained unchanged during the study. Strenuous three-week training consisting of repeated exercise bouts in healthy, sedentary individuals reduces monocyte chemotaxis. It remains to be established, whether this is a sound adaptation to increased stimuli or an untoward reaction to overtraining. Nevertheless, the effect remains for several weeks with no exercise.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?