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Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight

Artikel i vetenskaplig tidskrift
Författare Lorena López-Ferreras
Jennifer E. Richard
E. E. Noble
Kim Eerola
Rozita H Anderberg
Kajsa Olandersson
Lilly Taing
S. E. Kanoski
M. R. Hayes
Karolina P Skibicka
Publicerad i Molecular Psychiatry
Volym 23
Nummer/häfte 5
Sidor 1157-1168
ISSN 1359-4184
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 1157-1168
Språk en
Länkar https://doi.org/10.1038/mp.2017.187
Ämnesord glucagon-like peptide-1, ventral tegmental area, neural mechanisms, nucleus-accumbens, dopamine neurons, self-stimulation, energy-balance, reward, leptin, ghrelin, Biochemistry & Molecular Biology, Neurosciences & Neurology, Psychiatry
Ämneskategorier Psykiatri, Neurovetenskaper, Biokemi och molekylärbiologi

Sammanfattning

Increased motivation for highly rewarding food is a major contributing factor to obesity. Most of the literature focuses on the mesolimbic nuclei as the core of reward behavior regulation. However, the lateral hypothalamus (LH) is also a key reward-control locus in the brain. Here we hypothesize that manipulating glucagon-like peptide-1 receptor (GLP-1R) activity selectively in the LH can profoundly affect food reward behavior, ultimately leading to obesity. Progressive ratio operant responding for sucrose was examined in male and female rats, following GLP-1R activation and pharmacological or genetic GLP-1R blockade in the LH. Ingestive behavior and metabolic parameters, as well as molecular and efferent targets, of the LH GLP-1R activation were also evaluated. Food motivation was reduced by activation of LH GLP-1R. Conversely, acute pharmacological blockade of LH GLP-1R increased food motivation but only in male rats. GLP-1R activation also induced a robust reduction in food intake and body weight. Chronic knockdown of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males and females. Interestingly, increased food reinforcement was again found only in males. Our data identify the LH GLP-1R as an indispensable element of normal food reinforcement, food intake and body weight regulation. These findings also show, for we believe the first time, that brain GLP-1R manipulation can result in a robust and chronic body weight gain. The broader implications of these findings are that the LH differs between females and males in its ability to control motivated and ingestive behaviors.

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