Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Characterizing the behavi… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Characterizing the behavior, uptake, and toxicity of NM300K silver nanoparticles in Caenorhabditis elegans

Artikel i vetenskaplig tidskrift
Författare Merethe Kleiven
Lisa M. Rossbach
Julian A. Gallego-Urrea
Dag A. Brede
Deborah H. Oughton
Claire Coutris
Publicerad i Environmental Toxicology and Chemistry
Volym 37
Nummer/häfte 7
Sidor 1799-1810
ISSN 07307268
Publiceringsår 2018
Publicerad vid Institutionen för marina vetenskaper
Sidor 1799-1810
Språk en
Länkar https://doi.org/10.1002/etc.4144
Ämnesord Bioaccumulation, Characterization, Nanoparticles, Reproducibility, Toxic effects
Ämneskategorier Miljökemi, Tungmetaller och övriga metaller, Miljötoxikologi

Sammanfattning

© 2018 SETAC. Using Caenorhabditis elegans as a model organism, we addressed the potential linkage among toxicity of NM300K Ag nanoparticles (AgNPs), their particle size distribution, and the presence of dissolved Ag in the test media. Of the 3 endpoints assessed (growth, fertility, and reproduction), reproduction was the most sensitive, with the 50% effect concentration (EC50) ranging from 0.26 to 0.84mgAgL -1 and 0.08 to 0.11mgAgL -1 for NM300K and AgNO 3 , respectively. Silver uptake by C. elegans was similar for both forms of Ag, whereas bioaccumulation was higher in AgNO 3 exposure. The observed differences in toxicity between NM300K and AgNO 3 did not correlate with bioaccumulated Ag, which suggests that toxicity is a function of the type of exposing agent (AgNPs vs AgNO 3 ) and its mode of action. Before addition of the food source (Escherichia coli), size fractionation revealed that dissolved Ag comprised 13 to 90% and 4 to 8% of total Ag in the AgNO 3 and NM300K treatments, respectively. No dissolved Ag was detectable in the actual test media due to immediate Ag adsorption to bacteria. The results of the present study indicate that information on behavior and characterization of exposure conditions is essential for nanotoxicity studies.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?