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Subpopulations of extracellular vesicles and their therapeutic potential

Artikel i vetenskaplig tidskrift
Författare Cecilia Lässer
Su Chul Jang
Jan Lötvall
Publicerad i Molecular Aspects of Medicine
Volym 60
Sidor 1-14
ISSN 0098-2997
Publiceringsår 2018
Publicerad vid Krefting Research Centre
Institutionen för medicin
Sidor 1-14
Språk en
Länkar https://doi.org/10.1016/j.mam.2018....
Ämnesord Exosomes, Microvesicles, Microparticles, cell-derived nanovesicles, mesenchymal stem-cells, exosome-mimetic, nanovesicles, drug-delivery, membrane-vesicles, cancer-cells, plasma-membrane, messenger-rna, functional delivery, pancreatic-cancer, Biochemistry & Molecular Biology, Research & Experimental Medicine
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

Extracellular vesicles (EVs), such as exosomes and microvesicles, have over the last 10-15 years been recognized to convey key messages in the molecular communication between cells. Indeed, EVs have the capacity to shuttle proteins, lipids, and nucleotides such as RNA between cells, leading to an array of functional changes in the recipient cells. Importantly, the EV secretome changes significantly in diseased cells and under conditions of cellular stress. More recently, it has become evident that the EV secretome is exceptionally diverse, with many different types of EVs being released by a single cell type, and these EVs can be described in terms of differences in density, molecular cargos, and morphology. This review will discuss the diversity of EVs, will introduce some suggestions for how to categorize them, and will propose how EVs and their subpopulations might be used for very different therapeutic purposes.

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