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Effect of renal denervation on coronary flow reserve in patients with resistant hypertension

Artikel i vetenskaplig tidskrift
Författare Sebastian Völz
Bert Andersson
Charlotta Ljungman
Li-Ming Gan
Bengt Rundqvist
Sara Svedlund
Publicerad i Clinical Physiology and Functional Imaging
Volym 39
Nummer/häfte 1
Sidor 15-21
ISSN 1475-0961
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 15-21
Språk en
Länkar https://doi.org/10.1111/cpf.12523
Ämnesord ambulatory blood pressure monitoring; blood pressure; coronary circulation; denervation; hypertension; renal hypertension; sympathectomy
Ämneskategorier Kardiologi

Sammanfattning

Renal denervation (RDN) is a potential modality in the treatment of patients with resistant hypertension (RH) and has shown beneficial effect on a variety of cardiovascular surrogate markers. Coronary flow reserve, as assessed by transthoracic Doppler echocardiography (TDE-CFR) is impaired in patients with hypertension and is an independent predictor of cardiac morbidity. However, data on the effect of RDN on TDE-CFR are scarce. The main objective of this study was to assess the effect of RDN on TDE-CFR. Twenty-six consecutive patients with RH (9 female and 17 male; mean age 62 ± 8 years; mean number of antihypertensive drugs 4·2 ± 1·6) underwent bilateral RDN. CFR was assessed at baseline and 6 months after intervention. Mean flow velocity was measured in the left anterior descending artery by transthoracic Doppler echocardiography at baseline and during adenosine infusion (TDE-CFR). Systolic office blood pressure was reduced at follow-up (174 ± 24 versus 162 ± 27 mmHG; P = 0·01). Mean systolic ambulatory blood pressure decreased from 151 ± 21 to 147 ± 18 (P = 0·17). TDE-CFR remained unchanged 6 months after intervention (2·7 ± 0·6 versus 2·7 ± 0·7; P = 0·67). In conclusion, renal denervation was not associated with any changes in regard to coronary flow reserve at 6-month follow-up.

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