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Myocardial turnover of endogenous opioids and calcitonin-gene-related peptide in the human heart and the effects of spinal cord stimulation on pacing-induced angina pectoris.

Artikel i vetenskaplig tidskrift
Författare T Eliasson
C Mannheimer
Finn Waagstein
Bert Andersson
Claes-Håkan Bergh
L E Augustinsson
T Hedner
G Larson
Publicerad i Cardiology
Volym 89
Nummer/häfte 3
Sidor 170-7
ISSN 0008-6312
Publiceringsår 1998
Publicerad vid Wallenberglaboratoriet
Hjärt-kärlinstitutionen
Sidor 170-7
Språk en
Länkar dx.doi.org/10.1159/000006783
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Aged, Angina Pectoris, etiology, metabolism, rehabilitation, Calcitonin Gene-Related Peptide, metabolism, Cardiac Catheterization, Cardiac Pacing, Artificial, adverse effects, Electric Stimulation Therapy, Electrodes, Implanted, Enkephalin, Leucine, metabolism, Female, Humans, Male, Middle Aged, Myocardial Ischemia, etiology, metabolism, Myocardium, metabolism, Radioimmunoassay, Spinal Cord, physiology, beta-Endorphin, metabolism
Ämneskategorier Kardiologi

Sammanfattning

Earlier studies have shown that spinal cord stimulation (SCS) has antianginal and anti-ischemic effects in severe coronary artery disease. In the present study, 14 patients were subjected to right-sided atrial catheterization and atrial pacing. The patients were paced to angina during a control session and during spinal cord stimulation. Myocardial extraction of beta-endorphin (BE) during control pacing (8 +/- 22%) changed to release at the maximum pacing rate during treatment (-21 +/- 47%, a negative value representing release). Furthermore, the results indicate local myocardial turnover of leuenkephalin, BE and calcitonin-gene-related peptide. In addition, it is implied that SCS may induce myocardial release of BE which could explain the beneficial effects in myocardial ischemia.

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