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Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure.

Artikel i vetenskaplig tidskrift
Författare Bert Andersson
I Blange
C Sylvén
Publicerad i European journal of heart failure
Volym 1
Nummer/häfte 4
Sidor 363-9
ISSN 1388-9842
Publiceringsår 1999
Publicerad vid Wallenberglaboratoriet
Hjärt-kärlinstitutionen
Sidor 363-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Alleles, Female, Genotype, Heart Failure, genetics, mortality, physiopathology, Humans, Male, Middle Aged, Multivariate Analysis, Peptidyl-Dipeptidase A, genetics, Polymorphism, Genetic, Prognosis, Receptor, Angiotensin, Type 1, Receptor, Angiotensin, Type 2, Receptors, Angiotensin, genetics, Stroke Volume, Survival Rate, Sweden, epidemiology
Ämneskategorier Kardiologi

Sammanfattning

It has been suggested that a genetic polymorphism in the angiotensin II type 1 receptor gene (ATRG) and the ACE gene DD genotype might have a synergistic influence on the risk of developing cardiovascular disease.To study the possible interaction between polymorphisms in the ACE gene and the ATRG, regarding survival and left ventricular function.Polymorphism of the two genes was studied in a population-based cohort of 194 patients with idiopathic heart failure, recruited from the western part of Sweden 1985-1988. The patients were investigated by echocardiography. The survival status was checked during the 7-year follow-up period.Although there was no statistically significant additive risk of the ATRG polymorphism, patients carrying the ACE gene DD genotype in combination with a C allele of the ATRG tended to have a poorer prognosis. DD +AA, OR 1.24 (95% CI 0.67-2.32, P = 0.49); DD +AC, OR 1.64 (95% CI 0.95-2.83, P = 0.08); DD + CC, OR 3.54 95% CI 0.78-16.1, P = 0.10); DD +AC/CC, OR 1.84 (95% CI 1.10-3.08, P = 0.02). Patients with the DD +AC/CC genotypes tended to have lower ejection fraction and increased left ventricular mass.There was a trend toward a worse prognosis in patients with the combination of a C-allele in the ATRG and the ACE gene DD genotype, suggesting an interaction of these two genetic polymorphisms on disease severity.

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