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Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases.

Artikel i vetenskaplig tidskrift
Författare Inga Zerr
Matthias Schmitz
André Karch
Anna Villar-Piqué
Eirini Kanata
Ewa Golanska
Daniela Díaz-Lucena
Aikaterini Karsanidou
Peter Hermann
Tobias Knipper
Stefan Goebel
Daniela Varges
Theodoros Sklaviadis
Beata Sikorska
Pawel P Liberski
Isabel Santana
Isidro Ferrer
Henrik Zetterberg
Kaj Blennow
Olga Calero
Miguel Calero
Anna Ladogana
Raquel Sánchez-Valle
Inês Baldeiras
Franc Llorens
Publicerad i Alzheimer's & dementia : the journal of the Alzheimer's Association
Volym 14
Nummer/häfte 6
Sidor 751-763
ISSN 1552-5279
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 751-763
Språk en
Länkar dx.doi.org/10.1016/j.jalz.2017.12.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Neurofilament light, Cerebrospinal fluid, Neurodegenerative dementias, Prion diseases, Alzheimer's disease, Dementia with Lewy bodies, Parkinson's disease dementia, Vascular dementia, Frontotemporal dementia
Ämneskategorier Neurokemi

Sammanfattning

Neurofilament light (NFL) levels in the cerebrospinal fluid are increased in several neurodegenerative dementias. However, their diagnostic accuracy in the differential diagnostic context is unknown.Cerebrospinal fluid NFL levels were quantified in nonprimarily neurodegenerative neurological and psychiatric diseases (n = 122), mild cognitive impairment (n = 48), Alzheimer's disease (n = 108), dementia with Lewy bodies/Parkinson's disease dementia (n = 53), vascular dementia (n = 46), frontotemporal dementia (n = 41), sporadic Creutzfeldt-Jakob disease (sCJD, n = 132), and genetic prion diseases (n = 182).The highest NFL levels were detected in sCJD, followed by vascular dementia, frontotemporal dementia, dementia with Lewy bodies/Parkinson's disease dementia, Alzheimer's disease, and mild cognitive impairment. In sCJD, NFL levels correlated with cerebrospinal fluid tau and disease duration. NFL levels were able to differentiate sCJD from nonprimarily neurodegenerative neurological and psychiatric diseases (area under the curve = 0.99, 95% confidence interval: 0.99-1) and from the other diagnostic groups showing cognitive impairment/dementia of a non-CJD etiology (area under the curve = 0.90, 95% confidence interval: 0.87-0.92). Compared to nonprimarily neurodegenerative neurological and psychiatric diseases, NFL was also elevated in genetic prion diseases associated with the E200K, V210I, P102L, and D178N prion protein gene mutations.Increased NFL levels are a common feature in neurodegenerative dementias.

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