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Central and Peripheral Leptin and Agouti-Related Protein during and after Pregnancy in Relation to Weight Change.

Artikel i vetenskaplig tidskrift
Författare Ulrika Andersson Hall
Pernilla Svedin
Ulf Andreasson
Ameli Ingemansson
Henrik Zetterberg
Kaj Blennow
Aurimantas Pelanis
Carina Mallard
Agneta Holmäng
Publicerad i Clinical endocrinology
Volym 88
Nummer/häfte 2
Sidor 263-271
ISSN 1365-2265
Publiceringsår 2017
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 263-271
Språk en
Länkar dx.doi.org/10.1111/cen.13520
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord adipokines AGRP human neuropeptide postpartum pregnancy
Ämneskategorier Medicinska grundvetenskaper, Klinisk fysiologi

Sammanfattning

To study changes of neuropeptides and adipokines in cerebrospinal fluid (CSF) and serum from pregnancy to post-pregnancy in relation to weight changes, fat mass and glucose metabolism.With high postpartum weight retention being a risk factor in future pregnancies and of life-long obesity we evaluated neuropeptide and adipokine changes in women who either gained weight or were weight stable.Women were followed for 5±1 years after pregnancy and divided into two groups, Weight-Stable and Weight-Gain, by weight change from start of pregnancy.Twenty-five women (BMI 27±5kg/m2 ) recruited at admission for elective caesarean section.CSF and serum levels of agouti-related protein (AgRP), leptin, and insulin, and serum levels of adiponectin and soluble leptin receptor were measured during and after pregnancy. These measurements were further related to fat mass and insulin sensitivity (HOMA-IR).S-AgRP levels during pregnancy were lower in the Weight-Stable group and a 1 unit increase in s-AgRP was associated with 24% higher odds of pertaining to the Weight-Gain group. After pregnancy, s-AgRP increased in the Weight-Stable group but decreased in the Weight-Gain group. Decreased transport of leptin into CSF during pregnancy was reversed by an increased CSF:serum leptin ratio after pregnancy. In women who returned to their pre-pregnancy weight, serum adiponectin increased after pregnancy and correlated negatively with HOMA-IR.S-AgRP concentration in late pregnancy may be one factor predicting weight change after pregnancy, and circulating AgRP may be physiologically important in the long-term regulation of body weight. This article is protected by copyright. All rights reserved.

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