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Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature

Artikel i vetenskaplig tidskrift
Författare L. H. Mikkelsen
S. Andreasen
L. C. Melchior
Marta Persson
J. D. Andersen
V. Pereira
P. B. Toft
N. Morling
Göran Stenman
S. Heegaard
Publicerad i Oncology Letters
Volym 14
Nummer/häfte 4
Sidor 4176-4182
ISSN 1792-1074
Publiceringsår 2017
Publicerad vid Sahlgrenska Cancer Center
Institutionen för biomedicin, avdelningen för patologi
Sidor 4176-4182
Språk en
Länkar 10.3892/ol.2017.6713
Ämnesord Genetics, Lacrimal gland, Mitochondrial DNA, Oncocytic, Oncocytoma
Ämneskategorier Cancer och onkologi

Sammanfattning

The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei. The tumor cells stained strongly for antimitochondrial antibody MU213-UC, cytokeratin (CK) 5/6, CK 7, CK 17, CK 8/18 and CK 19. The final diagnosis was an oncocytoma of the lacrimal gland without any signs of malignancy. Array-based comparative genomic hybridisation demonstrated a gain of one copy of chromosome 8 and loss of one copy of chromosome 22 as the sole genomic imbalances. These chromosomal alterations have not previously been identified in oncocytoma and may be specific to lacrimal gland oncocytoma. Sequencing of the mitochondrial genome demonstrated multiple alterations of the NADH-ubiquinone oxidoreductase chain 5 (ND5) gene involved in mitochondrial oxidative phosphorylation. This may support the notion of a common genetic background of oncocytic lesions in the lacrimal gland and other anatomical sites. © 2017, Spandidos Publications. All rights reserved.

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