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Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone

Artikel i vetenskaplig tidskrift
Författare Furqan A. Shah
B. E. J. Lee
J. Tedesco
Cecilia Larsson Wexell
C. Persson
Peter Thomsen
K. Grandfield
Anders Palmquist
Publicerad i Nano Letters
Volym 17
Nummer/häfte 10
Sidor 6210-6216
ISSN 1530-6984
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 6210-6216
Språk en
Länkar doi.org/10.1021/acs.nanolett.7b0288...
Ämnesord Osteocyte lacuna, mineralization, micropetrosis, magnesium, whitlockite, bisphosphonates, beta-tricalcium phosphate, stabilizing impurity, in-vivo, mg, hydroxyapatite, beta-ca3(po4)2, homeostasis, osteocytes, apoptosis, apatite
Ämneskategorier Biomaterialvetenskap

Sammanfattning

Osteocytes are contained within spaces called lacunae and play a central role in bone remodelling. Administered frequently to prevent osteoporotic fractures, antiresorptive agents such as bi-sphosphonates suppress osteocyte apoptosis and may be localized within osteocyte lacunae. Bisphosphonates also reduce osteoclast viability and thereby hinder the repair of damaged tissue. Osteocyte lacunae contribute to toughening mechanisms. Following osteocyte apoptosis, the lacunar space undergoes mineralization, termed "micropetrosis". Hypermineralized lacunae are believed to increase bone fragility. Using nanoanalytical electron microscopy with complementary spectroscopic and crystallographic experiments, postapoptotic mineralization of osteocyte lacunae in bisphosphonate-exposed human bone was investigated. We report an unprecedented presence of similar to 80 nm to similar to 3 mu m wide, distinctly faceted, magnesium whitlockite [Ca18Mg2(HPO4)(2)(PO4)(12)] crystals and consequently altered local nanomechanical properties. These findings have broad implications on the role of therapeutic agents in driving biomineralization and shed new insights into a possible relationship between bisphosphonate exposure, availability of intracellular magnesium, and pathological calcification inside lacunae.

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