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Spirometric reference equations for Swedish adults

Artikel i vetenskaplig tidskrift
Författare Jonas Brisman
Jeong-Lim Kim
Anna-Carin Olin
Kjell Torén
Björn Bake
Publicerad i Clinical Physiology and Functional Imaging
Volym 37
Nummer/häfte 6
Sidor 640-645
ISSN 1475-0961
Publiceringsår 2017
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin
Sidor 640-645
Språk en
Länkar doi.org/10.1111/cpf.12349
Ämnesord adults, general population sample, lower limit normal, lung function, normal values, prediction, lung-function tests, exhaled nitric-oxide, reference values, prediction, equations, regression equations, population-sample, smoking variables, age, fraction, height, Physiology
Ämneskategorier Fysiologi

Sammanfattning

New spirometric reference equations for Swedish adults are required. Three different older sets of reference equations clinically used in Sweden have various drawbacks and the recently published 'The Global Lung Function 2012 (GLI) equations' have been shown not to be adequate for Swedish normal, healthy non-smokers. We have recently concluded that a piecewise linear model presented by Lubinski and Golczewski accurately describes the distribution of spirometric variables in a large Swedish random population sample. This piecewise linear model also offers the important advantage of implementing easily physiologically interpretable coefficients. The present study aimed at presenting piecewise linear reference equations for Swedish adults based on a random population sample of 6685 individuals aged 25-75years. Predicted normal values by the piecewise linear reference equations and lower limit normal (LLN) were compared with the three reference equations frequently used clinically in Sweden and the GLI equations. We found predicted normal values according to the present piecewise linear reference equations close to 100% predicted normal as expected, whereas the other equations either overestimated or underestimated normal subjects. Concerning LLN, the present equations, i.e. 1.645 x RSD, showed the least deviation from the expected 5% and, e.g., the GLI equations systematically identified too few subjects below LLN. We conclude that the present piecewise linear reference equations, based on a relatively large general population sample, ought to be considered for clinical use in Sweden. Application of 1.645 x RSD below predicted value gave an acceptably accurate LLN.

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