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Maturation-dependent expression of AIM2 in human B-cells

Artikel i vetenskaplig tidskrift
Författare Alexandra Svensson
Marianela Patzi Churqui
Kerstin Schlüter
Liza Lind
Kristina Eriksson
Publicerad i Plos One
Volym 12
Nummer/häfte 8
ISSN 1932-6203
Publiceringsår 2017
Publicerad vid Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Språk en
Länkar doi.org/10.1371/journal.pone.018326...
Ämnesord INNATE IMMUNITY, CYTOPLASMIC DNA, INFLAMMASOME, ACTIVATION, CANCER, PROLIFERATION, RESPONSES, SENSOR
Ämneskategorier Reumatologi och inflammation

Sammanfattning

Intracellular DNA-and RNA-sensing receptors, such as the IFN-inducible protein Absent in Melanoma 2 (AIM2), serve as host sensors against a wide range of infections. Immune sensing and inflammasome activation by AIM2 has been implicated in innate antiviral recognition in many experimental systems using cell-lines and animal models. However, little is known about the expression and function of AIM2 in freshly isolated human cells. In this study we investigated the expression of AIM2 in different cell types derived from human cord and adult peripheral blood, in steady state and following in vitro-activation. Adult but not cord blood B-cells expressed high levels of AIM2 mRNA at steady state. In adults, AIM2 was primarily expressed in mature memory CD27(+) B-cells. Both adult and cord blood derived B-cells could induce their transcription of AIM2 mRNA in response to type II IFN but not type I IFN or the AIM2 ligand poly dA:dT. Upon B-cell receptor stimulation, B-cells from adult blood expressed reduced levels of AIM2 mRNA. In addition, we show that adult B-cells were able to release IL-1 beta upon stimulation with synthetic DNA. We conclude that functional AIM2 is preferentially expressed in adult human CD27(+) B-cells, but is absent in cord blood mononuclear cells.

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