Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

PI3K gamma activity in le… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

PI3K gamma activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity

Artikel i vetenskaplig tidskrift
Författare Ludovic Breasson
Barbara Becattini
Claudia Sardi
A. Molinaro
F. Zani
R. Marone
F. Botindari
M. Bousquenaud
C. Ruegg
M. P. Wymann
Giovanni Solinas
Publicerad i Science Signaling
Volym 10
Nummer/häfte 488
ISSN 1945-0877
Publiceringsår 2017
Publicerad vid Wallenberglaboratoriet
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Språk en
Länkar 10.1126/scisignal.aaf2969
Ämnesord phosphoinositide 3-kinase gamma, diet-induced obesity, macrophage, polarization, metabolic syndrome, gut microbiota, ikk-beta, inhibition, fat, kinases, switch
Ämneskategorier Cell- och molekylärbiologi, Annan kemi

Sammanfattning

The phosphoinositide 3-kinase g (PI3K gamma) plays a major role in leukocyte recruitment during acute inflammation and has been proposed to inhibit classical macrophage activation by driving immunosuppressive gene expression. PI3K gamma plays an important role in diet-induced obesity and insulin resistance. In seeking to determine the underlying molecular mechanisms, we showed that PI3K gamma action in high-fat diet-induced inflammation and insulin resistance depended largely on its role in the control of adiposity, which was due to PI3K gamma activity in a nonhematopoietic cell type. However, PI3K gamma activity in leukocytes was required for efficient neutrophil recruitment to adipose tissue. Neutrophil recruitment was correlated with proinflammatory gene expression in macrophages in adipose tissue, which triggered insulin resistance early during the development of obesity. Our data challenge the concept that PI3K gamma is a general suppressor of classical macrophage activation and indicate that PI3K gamma controls macrophage gene expression by non-cell-autonomous mechanisms, the outcome of which is context-dependent.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?