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Impact of psychological health on peripheral endothelial function and the HPA-axis activity in healthy adolescents

Artikel i vetenskaplig tidskrift
Författare Yun Chen
W. Osika
Frida Dangardt
Peter Friberg
Publicerad i Atherosclerosis
Volym 261
Sidor 131-137
ISSN 0021-9150
Publiceringsår 2017
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 131-137
Språk en
Länkar doi.org/10.1016/j.atherosclerosis.2...
Ämnesord Adolescence, Negative emotional status, Self-concept, Peripheral endothelial function, Cortisol awakening response, coronary-heart-disease, cardiovascular-disease, salivary cortisol, physical-activity, children, childhood, stress, associations, dysfunction, depression, Cardiovascular System & Cardiology
Ämneskategorier Klinisk medicin

Sammanfattning

Background and aims: The development of adolescence psychological health over a 3-year period and its relationship to peripheral endothelial function and the hypothalamic-pituitary-adrenal (HPA)-axis activity were examined in a cohort of healthy adolescents in a longitudinal study. Methods: A total of 162 adolescents (94 females) participated in both baseline (mean age 14.5 +/- 1 years) and three-year follow-up studies. Psychological health was evaluated by self-report using the Beck Youth Inventories of Emotional and Social Impairment and the psychosomatic problem scale. Peripheral endothelial function was assessed using a peripheral artery tonometry device. The HPA-axis activity measured as cortisol awakening response (CAR) was assessed only at follow-up by collecting two saliva samples, immediately after awakening and 15 min later. Physical activity, smoking and parental education were assessed by questionnaires. Results: Adolescents reported increased depression and decreased anger over three years, while only females reported increased psychosomatic complaints. Reduced peripheral endothelial function was associated with high level of anger (beta = -0.332, p = 0.018) and disruptive behaviour (beta = -0.390, p = 0.006) over three years in males, but not in females, after adjusting for covariates. Blunted cortisol awakening response was associated with high level of anxiety (beta = -0.235, p = 0.017), depression (beta = -0.203, p = 0.038), anger (beta = -0.185, p = 0.048), and low level of self-concept (beta = 0.289, p = 0.002) after adjusting for covariates. Conclusions: High level of negative emotions during adolescence may have adverse effects on peripheral endothelial function and the regulation of the HPA- axis activity, while high level of self- concept might be protective. (C) 2017 Elsevier B.V. All rights reserved.

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