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Metabolic profiles from two different breakfast meals characterized by H-1 NMR-based metabolomics

Artikel i vetenskaplig tidskrift
Författare Millie Rådjursöga
B Göran Karlsson
Helen Lindqvist
Anders Pedersen
Cecilia Persson
R. C. Pinto
Lars Ellegård
Anna Winkvist
Publicerad i Food Chemistry
Volym 231
Sidor 267-274
ISSN 0308-8146
Publiceringsår 2017
Publicerad vid Svenskt NMR-centrum vid Göteborgs universitet
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 267-274
Språk en
Länkar 10.1016/j.foodchem.2017.03.142
Ämnesord Metabolomics, Nutrition, H-1 NMR, Urine, Metabolic phenotype, Biomarker, dietary exposure, untargeted metabolomics, coffee consumption, urine, metabolites, black tea, biomarkers, discovery, humans, food, metabonomics
Ämneskategorier Invärtesmedicin

Sammanfattning

It is challenging to measure dietary exposure with techniques that are both accurate and applicable to free-living individuals. We performed a cross-over intervention, with 24 healthy individuals, to capture the acute metabolic response of a cereal breakfast (CB) and an egg and ham breakfast (EHB). Fasting and postprandial urine samples were analyzed using H-1 nuclear magnetic resonance (NMR) spectroscopy and multivariate data analysis. Metabolic profiles were distinguished in relation to ingestion of either CB or EHB. Phosphocreatine/creatine and citrate were identified at higher concentrations after consumption of EHB. Beverage consumption (i.e., tea or coffee) could clearly be seen in the data. 2-furoylglycine and 5-hydroxymethyl-2-furoic acid - potential biomarkers for coffee consumption were identified at higher concentrations in coffee drinkers. Thus H-1 NMR urine metabolomics is applicable in the characterization of acute metabolic fingerprints from meal consumption and in the identification of metabolites that may serve as potential biomarkers. (C) 2017 Elsevier Ltd. All rights reserved.

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