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Prevalence of primary aldosteronism among patients with type 2 diabetes.

Artikel i vetenskaplig tidskrift
Författare Mauro Tancredi
Gudmundur Johannsson
Björn Eliasson
Robert Eggertsen
Ulf Lindblad
S Dahlqvist
Henrik Imberg
Marcus Lind
Publicerad i Clinical endocrinology
Volym 87
Nummer/häfte 3
Sidor 233–241
ISSN 1365-2265
Publiceringsår 2017
Publicerad vid Institutionen för matematiska vetenskaper
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 233–241
Språk en
Länkar dx.doi.org/10.1111/cen.13370
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Hälsovetenskaper, Klinisk medicin

Sammanfattning

Diabetes and hypertension coexist in 40-60% of individuals with type 2 diabetes. The coexistence of this two conditions is associated with increased risk of retinopathy, nephropathy and cardiovascular disease.To investigate the prevalence of primary aldosteronism (PA) in a general cohort of persons with type 2 diabetes.Cross-sectional study involving 6 diabetes outpatient clinics in Sweden.Were enrolled individuals with type 2 diabetes between February 2008 and December 2013.Plasma aldosterone concentrations (PAC pmol/L) and direct renin concentrations (DRC mIU/L) were measured. Patients with increased aldosterone renin ratios (ARR) >65 were further evaluated for PA.Of 578 consecutively screened patients with type 2 diabetes, 27 were treated with mineralocorticoid receptor antagonists (MRA) and potassium-sparing diuretics not further evaluated. Among the remaining 551 patients, 38 had increased ARR, including 22 who were clinically indicated for PA tests and 16 who were not further evaluated due to severe comorbidities and old age. There were 5 (0.93%) patients with confirmed PA after computerized tomography and adrenal venous sampling. Patients with PA had higher systolic blood pressure (p= 0.032) and lower potassium levels (p=0.027) than those without PA. No significant association was found between plasma aldosterone and diabetic complications.The prevalence of PA in an unselected cohort of patients with type 2 diabetes is relatively low, and measures of plasma aldosterone are not strong risk factors for micro- and macrovascular diabetic complications. This article is protected by copyright. All rights reserved.

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