Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Reduced DNA methylation a… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Reduced DNA methylation and psychopathology following endogenous hypercortisolism- a genome-wide study

Artikel i vetenskaplig tidskrift
Författare Camilla A M Glad
Johanna C. Andersson-Assarsson
Peter Berglund
Ragnhildur Bergthorsdottir
Oskar Ragnarsson
Gudmundur Johannsson
Publicerad i Scientific Reports
Volym 7
ISSN 2045-2322
Publiceringsår 2017
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Språk en
Länkar doi.org/10.1038/srep44445
Ämnesord receptor gene nr3c1, posttraumatic-stress-disorder, trans-retinoic acid, homeostatic synaptic plasticity, major depressive disorder, pituitary-adrenal axis, glucocorticoid-receptor, hpa-axis, cushings-syndrome, cognitive impairments, Science & Technology - Other Topics
Ämneskategorier Endokrinologi

Sammanfattning

Patients with Cushing's Syndrome (CS) in remission were used as a model to test the hypothesis that long-standing excessive cortisol exposure induces changes in DNA methylation that are associated with persisting neuropsychological consequences. Genome-wide DNA methylation was assessed in 48 women with CS in long-term remission (cases) and 16 controls matched for age, gender and education. The Fatigue impact scale and the comprehensive psychopathological rating scale were used to evaluate fatigue, depression and anxiety. Cases had lower average global DNA methylation than controls (81.2% vs 82.7%; p = 0.002). Four hundred and sixty-one differentially methylated regions, containing 3,246 probes mapping to 337 genes were identified. After adjustment for age and smoking, 731 probes in 236 genes were associated with psychopathology (fatigue, depression and/or anxiety). Twenty-four gene ontology terms were associated with psychopathology; terms related to retinoic acid receptor signalling were the most common (adjusted p = 0.0007). One gene in particular, COL11A2, was associated with fatigue following a false discovery rate correction. Our findings indicate that hypomethylation of FKBP5 and retinoic acid receptor related genes serve a potential mechanistic explanation for long-lasting GC-induced psychopathology.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?