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Consequences of growth hormone deficiency in adults and the benefits and risks of recombinant human growth hormone treatment. A review paper.

Författare T Rosén
Gudmundur Johannsson
J O Johansson
B A Bengtsson
Publicerad i Hormone research
Volym 43
Nummer/häfte 1-3
Sidor 93-9
ISSN 0301-0163
Publiceringsår 1995
Publicerad vid Institutionen för invärtesmedicin
Sidor 93-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Bone Density, drug effects, Cardiovascular Diseases, epidemiology, Evaluation Studies as Topic, Growth Hormone, adverse effects, deficiency, therapeutic use, Humans, Quality of Life, Recombinant Proteins, Risk Factors
Ämneskategorier Endokrinologi


Growth hormone deficiency (GHD) in adults is now recognized as a specific clinical syndrome with characteristic symptoms and signs. Thus, the patients are overweight, have an abnormal body composition (excess body fat and a decrease in the extracellular water volume) and a low bone mineral content compared to normals. Furthermore, the GHD patients have lipid abnormalities, decreased insulin sensitivity and a decreased fibrinolysis. Finally, the 'quality of life' is low in terms of energy and social life. Short- and long-term studies with recombinant human GH (rhGH) treatment have shown normalization of body composition, increase in the lipid pattern and marked improvement of the psychological well-being. The treatment seems safe with no serious side effects reported. In analogy with other hormonal replacement therapies, the rhGH dose should be individualized.

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