Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Cytokines in nasal fluids… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Cytokines in nasal fluids from school children with seasonal allergic rhinitis.

Artikel i vetenskaplig tidskrift
Författare Mikael Benson
Inga-Lisa Strannegård
Göran Wennergren
Örjan Strannegård
Publicerad i Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Volym 8
Nummer/häfte 3
Sidor 143-9
ISSN 0905-6157
Publiceringsår 1997
Publicerad vid Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi
Sidor 143-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Adult, Allergens, adverse effects, Child, Humans, Immunosorbents, Interferon-gamma, isolation & purification, Interleukin-10, isolation & purification, Interleukin-4, isolation & purification, Interleukin-5, isolation & purification, Interleukins, isolation & purification, Nasal Lavage Fluid, immunology, Pollen, Rhinitis, Allergic, Seasonal, immunology, physiopathology, Statistics, Nonparametric
Ämneskategorier Allergologi, Lungmedicin och allergi, Pediatrik

Sammanfattning

Allergic rhinitis is a particularly good model for studies of cytokine production in vivo. In this study the occurrence of the cytokines IL-4, IL-5, IL-10 and IFN-gamma as well as the soluble receptor for IL-4 in nasal lavage fluids were assayed in 38 school children, with seasonal allergic rhinitis, and 19 healthy age-matched, non-atopic controls, using highly sensitive enzyme immunoassays. IL-4 levels in patients with seasonal allergic rhinitis were markedly increased in comparison with those in non-atopic controls or in atopic patients before the start of the pollen season. In controls, but not in the atopic patients, levels of IFN-gamma and IL-5 were significantly higher in specimens obtained during the pollen season than in those obtained outside the season. The IL-4/IFN-gamma ratios were significantly higher in atopic than in non-atopic subjects and further increased in atopic patients during the season. In addition to IL-4, elevated levels of IL-10 were observed in association with seasonal rhinitis. Following treatment with a topical steroid (budesonide) there was a statistically significant increase of the levels of soluble IL-4 receptor. These findings indicate that nonatopic and atopic individuals react to pollen exposure with distinct cytokine patterns in agreement with the Th1/Th2 concept. Topical steroids may possibly decrease inflammation by increasing the formation of soluble IL-4 receptor.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?