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The influence of the molecular weight of the water-soluble polymer on phase-separated films for controlled release

Artikel i vetenskaplig tidskrift
Författare Helene Andersson
Henrike Häbel
Anna Olsson
Sofie Sandhagen
Christian von Corswant
Johan Hjärtstam
Michael Persson
Mats Stading
Anette Larsson
Publicerad i International Journal of Pharmaceutics
Volym 511
Nummer/häfte 1
Sidor 223-235
ISSN 0378-5173
Publiceringsår 2016
Publicerad vid Institutionen för matematiska vetenskaper, matematisk statistik
Sidor 223-235
Språk en
Länkar dx.doi.org/10.1016/j.ijpharm.2016.0...
Ämnesord Controlled release; Ethyl cellulose; Film coating; Hydroxypropyl cellulose; Molecular weight; Pellet formulation; Phase separation
Ämneskategorier Biomaterialvetenskap

Sammanfattning

Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC) can be used for extended release coatings, where the water-soluble HPC may act as a pore former. The aim was to investigate the effect of the molecular weight of HPC on the microstructure and mass transport in phase-separated freestanding EC/HPC films with 30% w/w HPC. Four different HPC grades were used, with weight averaged molecular weights (Mw) of 30.0 (SSL), 55.0 (SL), 83.5 (L) and 365 (M) kg/mol. Results showed that the phase-separated structure changed from HPC-discontinuous to bicontinuous with increasing Mw of HPC. The film with the lowest Mw HPC (SSL) had unconnected oval-shaped HPC-rich domains, leaked almost no HPC and had the lowest water permeability. The remaining higher Mw films had connected complex-shaped pores, which resulted in higher permeabilities. The highest Mw film (M) had the smallest pores and very slow HPC leakage, which led to a slow increase in permeability. Films with grade L and SL released most of their HPC, yet the permeability of the L film was three times higher due to greater pore connectivity. It was concluded that the phase-separated microstructure, the level of pore percolation and the leakage rate of HPC will be affected by the choice of HPC Mw grade used in the film and this will in turn have strong impact on the film permeability.

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