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Genomic profiling of a combined large cell neuroendocrine carcinoma of the submandibular gland

Artikel i vetenskaplig tidskrift
Författare S. Andreasen
Marta Persson
K. Kiss
P. Homoe
S. Heegaard
Göran Stenman
Publicerad i Oncology Reports
Volym 35
Nummer/häfte 4
Sidor 2177-2182
ISSN 1021-335X
Publiceringsår 2016
Publicerad vid Institutionen för biomedicin, avdelningen för patologi
Sahlgrenska Cancer Center
Sidor 2177-2182
Språk en
Länkar dx.doi.org/10.3892/or.2016.4621
Ämnesord large cell neuroendocrine carcinoma, salivary gland, submandibular gland, arrayCGH, combined, COPY scigloo.NUMBER ALTERATIONS, PAROTID-GLAND, LUNG, TUMORS, FUSION, CANCER, GENES, HEAD, NFIB, NECK
Ämneskategorier Molekylär medicin (genetik och patologi), Cancer och onkologi

Sammanfattning

A 69-year-old female with no previous medical history presented with a rapidly growing submandibular mass. Fine needle aspiration cytology suggested a small-cell carcinoma and PET-CT showed increased 18-FDG uptake in the submandibular mass as well as in a lung mass. Submandibular resection and selective neck dissection was performed and histopathologic examination revealed a combined large-cell neuroendocrine carcinoma (LCNEC) with a squamous component and without lymph node metastases. Resection of the lung tumor revealed a papillary adenocarcinoma that was morphologically distinctly different from the LCNEC. The patient died of her lung cancer after 19 months without evidence of recurrence of the LCNEC. Genomic profiling of the salivary gland LCNEC revealed a hypodiploid genome predominated by losses of whole chromosomes or chromosome arms involving chromosomes 3p, 4, 7q, 10, 11, 13, 16q and gains of 3q and 16p. In addition, there was a segmental gain of 9p23-p22.3 including the NFIB oncogene. Continued studies of salivary gland LCNEC may provide new knowledge concerning potential diagnostic biomarkers and may ultimately also lead to the identification of new treatment targets for patients with these aggressive carcinomas.

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