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Solid lipid nanoparticles from amphiphilic calixpyrroles

Artikel i vetenskaplig tidskrift
Författare Kaisa Helttunen
Albano Galan
Pablo Ballester
Johan Bergenholtz
Maija Nissinen
Publicerad i Journal of Colloid and Interface Science
Volym 464
Sidor 59–65
ISSN 0021-9797
Publiceringsår 2016
Publicerad vid Institutionen för kemi och molekylärbiologi
Sidor 59–65
Språk en
Länkar dx.doi.org/10.1016/j.jcis.2015.11.0...
Ämnesord Calixpyrrole, Macrocycle, solid-lipid nanoparticles, nanoparticle tracking, dynamic light scattering
Ämneskategorier Yt- och kolloidkemi, Fysikalisk organisk kemi

Sammanfattning

Hypothesis: Macrocyclic amphiphiles form interesting self-assembling structures, including solid lipid nanoparticles, which have potential applications in drug encapsulation. Aryl-extended calixpyrroles, which act as anion binding hosts, are expected to form solid lipid nanoparticles, even though the alkyl chains have unusual perpendicular geometry with respect to the hydrophilic head group. The preparation conditions and the alkyl chain length should affect the size and stability of the particles. Experiments: Solid lipid nanoparticles of two aryl-extended calixpyrroles with resorcinol walls and either meso-dodecyl or meso-methyl alkyl chains were compared. Ethanolic solutions of the calixpyrroles were mixed with water and the resulting nanoparticle dispersions were studied with dynamic light scattering and nanoparticle tracking analysis. The effect of different calixpyrrole/ethanol/water ratios on particle size was tested. The surface charge of the particles at different pH and NaCl concentration was determined by zeta potential measurements. Findings: The meso-dodecyl calixpyrrole produced small nanoparticles with mean hydrodynamic diameters between 40 and 70 nm in 0.86–4.28 M ethanol. The particles were stable in solution for several months. Particles prepared from meso-methyl calixpyrrole were larger and less stable. The smallest particles were obtained with low calixpyrrole concentration and calixpyrrole/ethanol ratio. Larger ethanol/water ratio induced broader particle size distributions. Increasing pH aided the stability of the particles due to increased negative surface charge.

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