Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Solvent Effects on Nitrog… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Solvent Effects on Nitrogen Chemical Shifts

Forskningsöversiktsartikel
Författare Hanna Andersson
Anna-Carin Carlsson
Bijan Nekoueishahraki
Ulrika Brath
Mate Erdelyi
Publicerad i Annual Reports on NMR Spectroscopy
Volym 86
Sidor 73-210
ISSN 0066-4103
Publiceringsår 2015
Publicerad vid Institutionen för kemi och molekylärbiologi
Sidor 73-210
Språk en
Länkar http://dx.doi.org/10.1016/bs.arnmr...
Ämnesord 15N NMR; chemical shift, solvent, 14N NMR, peptide, heterocycle,m protein, metal complex
Ämneskategorier Spektroskopi, Fysikalisk organisk kemi, Läkemedelskemi

Sammanfattning

Due to significant developments in cryogenic probe technology and the easy access to inverse detection pulse programmes (HSQC, HMBC), the sensitivity of nitrogen NMR has lately vastly improved. As a consequence, nitrogen NMR has turned into a useful and commonly available tool for solution studies of molecular structure and properties for small organic compounds likewise biopolymers. The high sensitivity of the nitrogen lone pair to changes in the molecular environment, alterations in intra- and intermolecular interactions, and in molecular conformation along with its wide, up to 1200 ppm chemical shift dispersion make nitrogen NMR to an exceptionally sensitive reporter tool. The nitrogen chemical shift has been applied in various fields of chemistry, including for instance the studies of transition metal complexes, chemical reactions such as N-alkylation and N-oxidation, tautomerization, protonation–deprotonation equilibria, hydrogen and halogen bonding, and elucidation of molecular conformation and configuration. The 15N NMR data observed in the investigation of these molecular properties and processes is influenced by the medium it is acquired in. This influence may be due to direct coordination of solvent molecules to transition metal complexes, alteration of tautomerization equilibria, and solvent polarity induced electron density changes of conjugated systems, for example. Thus, the solvent may significantly alter the observed nitrogen NMR shifts. This review aims to provide an overview of solvent effects of practical importance, and discusses selected experimental reports from various subfields of chemistry.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?