Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Salivary secretion and dr… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Salivary secretion and drug treatment in four 70-year-old Swedish cohorts during a period of 30 years

Artikel i vetenskaplig tidskrift
Författare Cecilia N Johanson
Tor Österberg
Bodil Lernfelt
Jörgen Ekström
Dowen Birkhed
Publicerad i Gerodontology
Volym 32
Nummer/häfte 3
Sidor 202-210
ISSN 0734-0664
Publiceringsår 2015
Publicerad vid Institutionen för odontologi
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 202-210
Språk en
Länkar dx.doi.org/10.1111/ger.12089
Ämnesord elderly, epidemiology, medication, population study, stimulated and unstimulated saliva, DRY MOUTH, GENERAL PRESENTATION, WHOLE SALIVA, AGE-GROUPS, POPULATION, PREVALENCE, PEOPLE, HEALTH, FLOW, HYPOSALIVATION, Dentistry, Oral Surgery & Medicine, Geriatrics & Gerontology
Ämneskategorier Endokrinologi och diabetes, Odontologi, Geriatrik

Sammanfattning

Objective The aim was to examine the association between drug treatment and unstimulated and stimulated whole saliva in four 70-year-old Swedish cohorts, between 1971 and 2001. Background Both diseases and their medication can affect the salivary secretion rate. Materials and methods The study was based on selected samples of four cohorts born in 1901/1902, 1906/1907, 1911/1912 and 1930/1931, respectively, a total of 1072 individuals. The response rate varied between 65% and 85%. Results The mean value for the stimulated salivary secretion rate was higher in men (1.30.8ml/min) than in women (1.0 +/- 0.7ml/min) (p<0.001)). There was a significant association between the salivary secretion rate and the number of drugs among both women (p<0.01) and men (p<0.001). This influence was most pronounced in participants who were treated with cardiovascular drugs, mainly diuretics and non-selective -adrenoceptor blockers, but also with antipsychotics and antidepressants, even when adjusted for cohort, gender, number of teeth and other drugs. There was an increase in treatment with medicines during the three decades. Conclusion In these four groups of 70-year-old participants, high drug consumption was associated with lower salivary flow. Unstimulated secretion was only affected in women and then, when taking four or more drugs. Pronounced hyposalivation was, however, uncommon. Cardiovascular drugs, antidepressants and antipsychotics were associated with low salivary secretion. In this age group, the frequently observed association between polypharmacy and a lower saliva secretion rate represents a risk of impaired dental health.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?