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The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia.

Artikel i vetenskaplig tidskrift
Författare Peter Johansson
Björn Andréasson
Soodabeh Safai-Kutti
Lovisa Wennström
Lars Palmqvist
Anne Ricksten
Göran Lindstedt
Jack Kutti
Publicerad i European journal of haematology
Volym 70
Nummer/häfte 6
Sidor 358-62
ISSN 0902-4441
Publiceringsår 2003
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för internmedicin
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Sidor 358-62
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Aged, 80 and over, Case-Control Studies, Cell Count, Erythropoietin, blood, Female, GPI-Linked Proteins, Granulocytes, cytology, Humans, Isoantigens, Male, Membrane Glycoproteins, Middle Aged, RNA, Messenger, analysis, biosynthesis, Receptors, Cell Surface, genetics, Thrombocytosis, blood, drug therapy, metabolism, Up-Regulation
Ämneskategorier Hematologi, Klinisk laboratoriemedicin

Sammanfattning

Approximately 45% of newly diagnosed patients with essential thrombocythaemia (ET) demonstrate subnormal plasma erythropoietin (EPO) concentrations, which constitutes a risk factor for occlusive vascular events. In 58 ET patients, a possible association between polycythaemia rubra vera-1 (PRV-1) overexpression and subnormal plasma EPO was investigated, which was always measured prior to the institution of platelet lowering agents. At the time when PRV-1 expression was measured, 28 of 58 (48%) ET patients had received platelet lowering treatment. PRV-1 expression was measured by quantitative real-time reverse transcription-polymerase chain reaction assay of mRNA extracted from purified peripheral blood buffy coat. The cycle threshold (CT) value of PRV-1 was determined and was divided with the CT value for the housekeeping GAPDH gene transcript. A quotient <0.93 was defined as PRV-1 positive. Of the ET patients 12 of 58 (21%) were PRV-1 positive and 19 of 58 (33%) demonstrated subnormal plasma EPO. In the 58 ET patients there was a significant association between low plasma EPO and PRV-1 positive results (P = 0.001). The 30 ET patients who had not received any platelet lowering treatment showed a significant (P = 0.005) relation between PRV-1 positivity and subnormal plasma EPO. No such relationship was present in the 28 ET patients who had received prior treatment with the above drugs (P = 0.147).

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