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Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches.

Artikel i vetenskaplig tidskrift
Författare Anna Ermund
André Schütte
Malin E V Johansson
Jenny K Gustafsson
Gunnar C. Hansson
Publicerad i American journal of physiology. Gastrointestinal and liver physiology
Volym 305
Nummer/häfte 5
Sidor G341-7
ISSN 1522-1547
Publiceringsår 2013
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor G341-7
Språk en
Länkar dx.doi.org/10.1152/ajpgi.00046.2013
Ämnesord Adhesiveness, Animals, Carbachol, pharmacology, Colon, drug effects, metabolism, microbiology, Dinoprostone, pharmacology, Female, Fluorescent Dyes, metabolism, Gastric Mucosa, drug effects, metabolism, microbiology, Intestinal Absorption, Intestinal Mucosa, drug effects, metabolism, microbiology, Intestine, Small, drug effects, metabolism, microbiology, Male, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Microscopy, Video, Mucus, metabolism, microbiology, Permeability, Peyer's Patches, drug effects, metabolism, Time Factors
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

Colon has been shown to have a two-layered mucus system where the inner layer is devoid of bacteria. However, a complete overview of the mouse gastrointestinal mucus system is lacking. We now characterize mucus release, thickness, growth over time, adhesive properties, and penetrability to fluorescent beads from stomach to distal colon. Colon displayed spontaneous mucus release and all regions released mucus in response to carbachol and PGE2, except the distal colon and domes of Peyer's patches. Stomach and colon had an inner mucus layer that was adherent to the epithelium. In contrast, the small intestine and Peyer's patches had a single mucus layer that was easily aspirated. The inner mucus layer of the distal colon was not penetrable to beads the size of bacteria and the inner layer of the proximal colon was only partly penetrable. In contrast, the inner mucus layer of stomach was fully penetrable, as was the small intestinal mucus. This suggests a functional organization of the intestinal mucus system, where the small intestine has loose and penetrable mucus that may allow easy penetration of nutrients, in contrast to the stomach, where the mucus provides physical protection, and the colon, where the mucus separates bacteria from the epithelium. This knowledge of the mucus system and its organization improves our understanding of the gastrointestinal tract physiology.

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