Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Involvement of non-NMDA r… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Involvement of non-NMDA receptors in central mediation of chemoreflexes in the shorthorn sculpin, Myoxocephalus scorpius

Artikel i vetenskaplig tidskrift
Författare Jenny Turesson
Marcus Johansson
Lena Sundin
Publicerad i Respiratory Physiology & Neurobiology
Volym 172
Nummer/häfte 3
Sidor 83-93
ISSN 1569-9048
Publiceringsår 2010
Publicerad vid Zoologiska institutionen
Sidor 83-93
Språk en
Länkar dx.doi.org/10.1016/j.resp.2010.03.0...
Ämnesord Teleost, Hypoxia, Respiration, Ventilation, Cardiovascular, Nucleus tractus solitarius, Glutamate, AMPA, NMDA, Kainate, Ionotropic
Ämneskategorier Zoofysiologi

Sammanfattning

NMDA receptors mediate hypoxia-induced ventilatory frequency and blood pressure increases in fish. Here we continue to resolve whether non-NMDA receptors participate in chemoreflexes. Shorthorn sculpins, instrumented for cardiorespiratory measurements, were kept unrestrained or positioned in a stereotaxic frame. Chemoreflexes were elicited (hypoxia/NaCN-induced) before/after administration of either the specific AMPA receptor antagonist, GYKI52466 (systemically), or the specific kainate receptor antagonist, UBP293 (microinjections into fourth ventricle). Immunohistochemistry was performed on medullary cross-sections to identify non-NMDA receptor subunits in the chemoreflex-pathway. Kainate receptors mediate the chemoreflex-mediated increase in ventilation amplitude, since the response was abolished by UBP293. GYKI52466 attenuated the ventilatory frequency increase, and induced more regular breathing patterns and higher heart rate in both normoxic and hypoxic conditions, suggesting that AMPA receptors also partake in cardiorespiratory control. This together with immunohistochemical findings of both AMPA and kainate receptor subunits in the chemoreflex-pathway, show that non-NMDA receptors play a role in both chemoreflex-activation and normoxic cardiorespiratory regulation in fish. (C) 2010 Published by Elsevier.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?