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Physical Activity, Weight Status, Diabetes and Dementia: A 34-Year Follow-Up of the Population Study of Women in Gothenburg

Artikel i vetenskaplig tidskrift
Författare Kirsten Mehlig
Ingmar Skoog
Margda Waern
Junmei Miao Jonasson
L. Lapidus
Cecilia Björkelund
Svante Östling
Lauren Lissner
Publicerad i Neuroepidemiology
Volym 42
Nummer/häfte 4
Sidor 252-259
ISSN 0251-5350
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Sidor 252-259
Språk en
Länkar dx.doi.org/10.1159/000362201
Ämnesord Dementia, Diabetes, Leisure time physical activity, Obesity, Midlife risk factors, Population cohort, ALZHEIMERS-DISEASE, INSULIN-RESISTANCE, SWEDISH WOMEN, RISK-FACTORS, LATE-LIFE, OBESITY, OVERWEIGHT, SWEDEN, MORTALITY, TRENDS, Public, Environmental & Occupational Health, Clinical Neurology
Ämneskategorier Neurologi, Endokrinologi och diabetes

Sammanfattning

Background: There is evidence of a synergistic interaction between obesity and sedentary lifestyle with respect to diabetes. Although diabetes is a known risk factor for dementia, it is unclear if both diseases have common aetiologies. Methods: A community-based sample of 1,448 Swedish women, aged 38-60 years and free of diabetes and dementia in 1968, was followed by means of up to 5 examinations spread over 34 years. 9.6% of all women developed diabetes and 11.4% developed dementia (over 40,000 person-years of follow-up for each disease). Cox proportional hazard regression was used to assess the influence of selected risk factors on both diseases, and the relation between diabetes and dementia. Results: Comparing risk factors for incident diabetes and dementia, both diseases showed a synergistic association with obesity combined with a low level of leisure time physical activity [hazard ratio (HR) for interaction = 2.7, 95% confidence interval (Cl) = 1.2-6.3 for diabetes and HR = 3.3, 95% Cl = 1.1-9.9 for dementia]. Development of diabetes doubled the risk for subsequent dementia (HR = 2.2, 95% Cl = 1.1-4.4), which was slightly reduced upon adjustment for common risk factors. Conclusions: Shared risk factors suggest a similar aetiology for diabetes and dementia and partially explain the association between diseases. (C) 2014 S. Karger AG, Basel

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