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Mortality and morbidity 1 year after early thrombolysis in suspected AMI: results from the TEAHAT Study.

Artikel i vetenskaplig tidskrift
Författare Johan Herlitz
Mikael Dellborg
Marianne Hartford
Thomas Karlsson
Martin Risenfors
Björn W. Karlson
Russel Luepker
Stig Holmberg
Karl Swedberg
Åke Hjalmarson
Publicerad i Journal of internal medicine. Supplement
Volym 734
Sidor 43-51
ISSN 0955-7873
Publiceringsår 1991
Publicerad vid Hjärt-kärlinstitutionen
Sidor 43-51
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Aged, Ambulatory Care, Angina Pectoris, mortality, Angioplasty, Balloon, Coronary, Coronary Artery Bypass, Electrocardiography, Exercise Test, Follow-Up Studies, Humans, Length of Stay, Myocardial Infarction, drug therapy, mortality, physiopathology, therapy, Survival Rate, Thrombolytic Therapy, Tissue Plasminogen Activator, therapeutic use
Ämneskategorier Klinisk medicin

Sammanfattning

We randomized 352 patients with suspected acute myocardial infarction (AMI) to treatment with rt-PA (n = 177) or placebo (n = 175). Patients were eligible if evaluated within 2 h and 45 min from onset of chest pain, and if aged less than 75 years. There were no ECG criteria for inclusion. A mobile coronary-care unit with a cardiologist present was used to initiate treatment at home in 29% of cases. During 1 year of follow-up the mortality in patients treated with rt-PA was 10.2%, as compared with 14.3% in patients the initial ECG, the mortality during the first year was 8% in the rt-PA group vs. 18% in the placebo group (P less than 0.05). Among patients without ST-elevation the mortality was 9% for the rt-PA group vs. 12% for the placebo group (NS). Requirement for rehospitalization, symptoms of angina pectoris and congestive heart failure, time of return to work and requirement for various medications did not differ significantly between the two groups, regardless of the initial ECG pattern.

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