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Parasympathetic vasoactive intestinal peptide (VIP): a likely contributor to clozapine-induced sialorrhoea

Artikel i vetenskaplig tidskrift
Författare Jörgen Ekström
Tania Godoy
F. Loy
A. Riva
Publicerad i Oral Diseases
Volym 20
Nummer/häfte 3
Sidor e90-e96
ISSN 1354-523X
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor e90-e96
Språk en
Länkar dx.doi.org/10.1111/odi.12139
Ämnesord schizophrenia, clozapine-induced sialorrhoea, vasoactive intestinal peptide, salivary secretion, HUMAN SUBMANDIBULAR-GLAND, CARBACHOL-INDUCED K+, SALIVARY FLOW-RATE, RAT, PAROTID-GLAND, SUBSTANCE-P, N-DESMETHYLCLOZAPINE, SECRETION, RECEPTORS, PROTEIN, NERVE
Ämneskategorier Farmakologi, Oral mikrobiologi

Sammanfattning

Objective The parasympathetic transmitter vasoactive intestinal peptide (VIP) increases salivary gland blood flow and evokes protein secretion and, in some species, such as rats, a small fluid secretion. It interacts synergistically with muscarinics for protein and fluid output. Human salivary acini are supplied with VIP-containing nerves. We hypothesise that VIP and clozapine, acting together, evoke a volume of saliva greater than the sum of those induced by each drug given separately. It was further considered whether, in the current test situation, circulatory events influenced the magnitude of the secretory response. Saliva from parotid glands deprived of their autonomic innervation, and saliva and blood from innervated submandibular glands were collected in adrenoceptor antagonist-pretreated pentobarbitone-anaesthetised rats. Initially, the individual and then the combined effects of intravenous doses of VIP and clozapine were established. The submandibular volume response to the combination was 2-3 times higher, while blood pressure and glandular blood flow did not differ from those to VIP alone. The synergism occurred independent of nerves as shown in denervated parotid glands. From the current preclinical data, we speculate that VIP of parasympathetic origin, by its synergistic interaction with clozapine, may contribute to the clozapine (muscarinic M1-receptor)-induced sialorrhoea in schizophrenics.

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