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A maternal diet of fatty fish reduces body fat of offspring compared with a maternal diet of beef and a post-weaning diet of fish improves insulin sensitivity and lipid profile in adult C57BL/6 male mice.

Artikel i vetenskaplig tidskrift
Författare A. Hussain
Intawat Nookaew
Sakda Khoomrung
L. Andersson
Ingrid Larsson
Lena Hulthén
Nina Jansson
Robert Jakubowicz
Staffan Nilsson
Ann-Sofie Sandberg
Jens B. Nielsen
Agneta Holmäng
Publicerad i Acta Physiologica
Volym 209
Nummer/häfte 3
Sidor 220-234
ISSN 1748-1708
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för matematiska vetenskaper, matematisk statistik
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 220-234
Språk en
Länkar dx.doi.org/10.1111/apha.12130
Ämnesord body composition, fatty fish, insulin sensitivity, maternal diet, n-6/n-3 ratio, red meat
Ämneskategorier Näringslära

Sammanfattning

Aim The maternal diet during pregnancy and lactation may affect the long-term health of the offspring. Our aim was to study how a fish or meat diet perinatal and after weaning affects body composition, insulin sensitivity and the profile of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in breast milk, fat depots, skeletal muscle and liver in male adult mice offspring. Methods During gestation and lactation, C57BL/6 dams were fed a herring- or beef-based diet. Half of the pups in each group changed diets after weaning. In offspring, body composition measured by DEXA, plasma lipid profile and insulin sensitivity measured by euglycemic clamp or QUICKI were monitored to adulthood. Analysis of total FAs by GC-MS were performed in the diet, breast milk and in different tissues. Results At 9 week of age, offspring of herring-fed dams had less body fat than offspring of beef-fed dams. Mice fed herring after weaning had increased insulin sensitivity at 15 week of age, reduced total plasma cholesterol and triglyceride levels, and compared with beef-fed mice, larger interscapular brown adipose tissue depots. The FA composition of the maternal diet was mirrored in breast milk, and the herring diet significantly affected the FA profile of different tissues, leading to an increased content of n-3 PUFAs. Conclusion A herring-based maternal diet reduces body fat in the offspring, but the insulin sensitivity, plasma lipids and amount of brown adipose tissue are affected by the offspring's own diet; the herring diet is more beneficial than the beef diet.

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