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Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds.

Artikel i vetenskaplig tidskrift
Författare Peter Tarnow
M Agren
H Steenfos
John-Olov Jansson
Publicerad i Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi
Volym 28
Nummer/häfte 4
Sidor 255-9
ISSN 0284-4311
Publiceringsår 1994
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för plastikkirurgi
Institutionen för invärtesmedicin
Sidor 255-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Administration, Topical, Animals, Female, Gene Expression, drug effects, Granulation Tissue, chemistry, metabolism, Insulin-Like Growth Factor I, genetics, metabolism, Nucleic Acid Hybridization, RNA, Messenger, analysis, Skin, injuries, Swine, Wound Healing, drug effects, Zinc, analysis, physiology, Zinc Oxide, administration & dosage, therapeutic use
Ämneskategorier Plastikkirurgi

Sammanfattning

Application of zinc oxide has been shown to accelerate the healing of both chronic and acute wounds, but the mechanisms are unknown. We quantified the gene expression (mRNA) for one important growth factor, insulin-like growth factor-1 (IGF-1) in 12 full-thickness wounds in each of three domestic pigs treated with or without topical zinc oxide. We used a RNAase protection/solution hybridisation technique to measure IGF-1 mRNA concentrations, which were 50% higher in the granulation tissue in wounds treated with zinc oxide compared with control wounds on days 3-4 (p < 0.05), but not thereafter (up to postoperative day 11). Topical zinc oxide increased the healing rate of wounds compared to the control group (p < 0.01). The cell composition of the granulation tissue was similar in the two groups. The increased gene expression of IGF-1 may be one mechanism by which topical zinc oxide enhances wound healing.

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