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Bicarbonate-sensitive cysteine induced elevation of extracellular aspartate and glutamate in rat hippocampus in vitro

Artikel i vetenskaplig tidskrift
Författare Abdul-Karim Abbas
Kent Jardemark
Anders Lehmann
Stephen Weber
Mats Sandberg
Publicerad i Neurochemistry International
Volym 30
Nummer/häfte 3
Sidor 253-259
ISSN 0197-0186
Publiceringsår 1997
Publicerad vid Institutionen för anatomi och cellbiologi
Sidor 253-259
Språk en
Länkar www.sciencedirect.com/science/artic...
Ämnesord uptake; cysteine sulfinate; cystine; carrier; diacidic; carbon dioxide
Ämneskategorier Medicinska grundvetenskaper, Neurovetenskaper, Neurokemi

Sammanfattning

The effect of different concentrations of cysteine (0.125, 0.25, 0.5 and 1 mM) on the net efflux of endogenous amino acids was studied by the incubation of rat hippocampal slices. Addition of cysteine (1 mM) in bicarbonate containing low K+ medium (5 min) selectively increased the basal net efflux of glutamate and aspartate by 370% and 396%, respectively. High K+ media (50 mM) containing cysteine (1 mM) evoked the net efflux of glutamate and aspartate by 1 454% and 1 019%, respectively. The corresponding effects in control slices without cysteine were 669% and 404%, respectively. No changes were observed on the concentrations of GABA, glutamine and taurine. The cysteine oxidation products, cysteine sulfinate (0.5 μM) and cystine (0.25 mM) were without effects. The effect of cysteine (0.5 mM) was dramatically reduced in media with no added bicarbonate/CO2. Thus, cysteine in a bicarbonate-sensitive manner selectively increases the extracellular concentration of excitotoxic amino acids in adult rat brain in vitro, possibly by interfering with the carrier-mediated glutamate uptake/ release

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