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Intraoperative detection of somatostatin-receptor-positive neuroendocrine tumours using indium-111-labelled DTPA-D-Phe1-octreotide.

Artikel i vetenskaplig tidskrift
Författare Bo Wängberg
Eva Forssell-Aronsson
Lars-Eric Tisell
Ola Nilsson
M Fjalling
Håkan Ahlman
Publicerad i British journal of cancer
Volym 73
Nummer/häfte 6
Sidor 770-5
ISSN 0007-0920
Publiceringsår 1996
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för radiofysik
Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 770-5
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Carcinoid Tumor, radionuclide imaging, surgery, ultrastructure, Female, Humans, Indium Radioisotopes, diagnostic use, Intraoperative Care, Neuroendocrine Tumors, radionuclide imaging, surgery, ultrastructure, Octreotide, analogs & derivatives, diagnostic use, Pancreatic Neoplasms, radionuclide imaging, surgery, ultrastructure, Pentetic Acid, analogs & derivatives, diagnostic use, Receptors, Somatostatin, analysis, Stomach Neoplasms, radionuclide imaging, surgery, ultrastructure, Thyroid Neoplasms, radionuclide imaging, surgery, ultrastructure, Uterine Cervical Neoplasms, radionuclide imaging, surgery, ultrastructure
Ämneskategorier Radiofysik, Gastroenterologi, Kirurgi, Cancer och onkologi

Sammanfattning

After injection of 111In-labelled DTPA-D-Phe1-octreotide, intraoperative tumour localisation was performed using a scintillation detector in 23 patients with neuroendocrine tumours. Count rates from suspect tumour lesions and adjacent normal tissue were expressed as a ratio before (Rin situ) and after (Rex vivo) excision. 111In activity concentration ratios of tumour tissue to blood (T/B) were determined in a gamma counter. In patients with midgut carcinoids, (all scintigraphy positive), false Rin situ recordings were found in 4/29 macroscopically identified tumours. T/B ratios were all high (27-650). In patients with medullary thyroid carcinomas (eight out of ten scintigraphy positive), misleading Rin situ results were found in 4/37 macroscopically identified tumours. T/B ratios were lower (3-39) than those seen in midgut carcinoids. Two out of four patients with endocrine pancreatic tumours had positive scintigraphy, reliable intraoperative measurements and very high T/B ratios (910-1500). One patient with a gastric carcinoid had correct measurements in situ and ex vivo with high T/B ratios (71-210). In situ measurements added little information to preoperative scintigraphy and surgical findings using the present detection system. Rex vivo measurements were more reliable. The very high T/B ratios seen in midgut carcinoids and some endocrine pancreatic tumours would be favourable for future radiation therapy via somatostatin receptors.

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