Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Rapid induction of entero… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Rapid induction of enterochromaffinlike cell tumors by histamine2-receptor blockade.

Artikel i vetenskaplig tidskrift
Författare O Nilsson
Bo Wängberg
L Johansson
E Theodorsson
A Dahlström
I M Modlin
Håkan Ahlman
Publicerad i The American journal of pathology
Volym 142
Nummer/häfte 4
Sidor 1173-85
ISSN 0002-9440
Publiceringsår 1993
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 1173-85
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Chromogranins, metabolism, Dose-Response Relationship, Drug, Endocrine Gland Neoplasms, chemically induced, metabolism, pathology, Endocrine Glands, metabolism, pathology, Enterochromaffin Cells, metabolism, pathology, Histamine, metabolism, Histamine H2 Antagonists, Muridae, Reference Values, Silver, Stomach Neoplasms, chemically induced, metabolism, pathology, Triazoles, administration & dosage, pharmacology
Ämneskategorier Gastroenterologi, Kirurgi

Sammanfattning

The effect of acid inhibition on gastric endocrine cells was investigated in Praomys (Mastomys) natalensis. Long-term treatment (1 to 32 weeks) with an irreversible histamine 2-receptor blocker (loxtidine) caused a sustained increase in plasma gastrin levels, which was accompanied by a gradual increase in histamine and histidine decarboxylase activity of the gastric oxyntic mucosa. The density of endocrine cells in the oxyntic mucosa increased gradually, doubled by 8 weeks, and was three times that of controls after 24 weeks of treatment. Hyperplastic changes in the endocrine cell population were evident after 2 to 8 weeks in all animals, whereas dysplastic or neoplastic lesions were observed in half the animals after 16, 24, and 32 weeks of treatment. Gross tumors in the oxyntic mucosa were observed in 1/4 of the animals treated for 24 or 32 weeks. Proliferating cells were identified as enterochromaffinlike cells because they were argyrophilic and immunopositive for chromogranin A and histamine. The results demonstrate that histamine 2-receptor blockade initiated by loxtidine promotes a rapid development of enterochromaffinlike cell tumors in Mastomys and suggest a critical role for gastrin in the formation of these tumors. However, the rate and frequency by which carcinoid tumors appeared in Mastomys after acid inhibition was much greater than that reported in other species, indicating that several factors, including hormonal and genetic factors, are important in the development of gastric endocrine tumors.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?