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Antibody-dependent cell-mediated cytotoxicity to gliadin-coated cells with sera from children with coeliac disease.

Artikel i vetenskaplig tidskrift
Författare Robert Saalman
Agnes E Wold
Ulf Dahlgren
S P Fällström
Lars Åke Hanson
Staffan Ahlstedt
Publicerad i Scandinavian journal of immunology
Volym 47
Nummer/häfte 1
Sidor 37-42
ISSN 0300-9475
Publiceringsår 1998
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 37-42
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Antibody-Dependent Cell Cytotoxicity, immunology, Celiac Disease, blood, immunology, Enzyme-Linked Immunosorbent Assay, Female, Gliadin, immunology, Humans, Immunoglobulin A, blood, Immunoglobulin G, blood, Infant, Intestinal Mucosa, immunology, Intestine, Small, immunology, Macrophages, immunology, Male, Monocytes, immunology
Ämneskategorier Gastroenterologi, Pediatrik, Immunologi inom det medicinska området

Sammanfattning

Antibody-dependent cell-mediated cytotoxicity (ADCC) has been suggested as a contributing immunological mechanism in the disease process of coeliac disease. In the present study, sera from coeliac children were examined for their capacity to mediate ADCC against gliadin-coated target cells. The ADCC-mediating efficacy of sera were tested using monocytes from healthy adults as effector cells and gliadin-coated erythrocytes from the same donor as targets. Using monocytes as effector cells, sera from children with active coeliac disease (untreated or challenged), demonstrated significantly higher ADCC-mediating capacity than sera from healthy and disease references as well as children with treated coeliac disease. A positive correlation was found between the ADCC-mediating capacity and serum IgG as well as IgA anti-gliadin antibody levels. The results suggest that an antibody-dependent monocyte/macrophage-induced cytotoxic reaction might be involved in the disease process of coeliac disease.

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