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Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men.

Artikel i vetenskaplig tidskrift
Författare Intawat Nookaew
Per-Arne Svensson
Peter Jacobson
Margareta Jernås
Magdalena Taube
Ingrid Larsson
Johanna C. Andersson-Assarsson
Lars Sjöström
Philippe Froguel
Andrew Walley
Jens B. Nielsen
Lena M S Carlsson
Publicerad i The Journal of clinical endocrinology and metabolism
Volym 98
Nummer/häfte 2
Sidor E370-E378
ISSN 1945-7197
Publiceringsår 2013
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor E370-E378
Språk en
Länkar dx.doi.org/10.1210/jc.2012-2764
Ämneskategorier Klinisk medicin

Sammanfattning

Context:Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity treatment.Objective:The objective of the study was a search for sex differences in adipose tissue function.Design and Setting:This was an exploratory study performed at a university hospital.Participants and Main Outcome Measures:Resting metabolic rate (RMR), body composition, and sc adipose tissue genome-wide expression were measured in the SOS Sib Pair study (n = 732).Results:The relative contribution of fat mass to RMR and the metabolic rate per kilogram adipose tissue was higher in women than in men (P value for sex by fat mass interaction = .0019). Women had increased expression of genes involved in mitochondrial function, here referred to as a mitochondrial gene signature. Analysis of liver, muscle, and blood showed that the pronounced mitochondrial gene signature in women was specific for adipose tissue. Brown adipocytes are dense in mitochondria, and the expression of the brown adipocyte marker uncoupling protein 1 was 5-fold higher in women compared with men in the SOS Sib Pair Study (P = 7.43 × 10(-7)), and this was confirmed in a cross-sectional, population-based study (n = 83, 6-fold higher in women, P = .00256).Conclusions:The increased expression of the brown adipocyte marker uncoupling protein 1 in women indicates that the higher relative contribution of the fat mass to RMR in women is in part explained by an increased number of brown adipocytes.

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